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About Cyclomune® Eye Drops

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Cyclomune® eye drops are manufactured by Sun Pharmaceutical. The active substance of this medication is Cyclosporine, an immunosuppressant and selective inhibitor of cytokine production and functioning.

Cyclomune® eye drops are indicated when eyes are not able to produce enough tears due to ocular inflammation associated with keratoconjunctivitis sicca (KCS). Dry eye disease, also called dry eye syndrome (DES) or keratoconjunctivitis sicca, is mostly characterized by dry and easily fatigued eyes, irritation, redness, discharge, blurred vision.

MOA (mechanism of action):

Cyclosporine is a topical calcineurin inhibitor. Diffusing into a T cell (T lymphocyte), Cyclosporine binds to calcineurin, that is responsible for T cells activation. When calcineurin is suppressed, Cyclosporine reduces the number of T lymphocytes thereby blocking immune reactions causing the inflammation. By these actions Cyclosporine cures the ocular inflammation and allows for tear production.


Instill one drop into the treated eye(s) 2 times daily with 12 hours interval.

Artificial tears may be used concurrently, allowing a 15-minute interval between administration of products.


Cyclomune® eye drops are not intended for use in children under 16 year of age.

Cyclomune® eye drops are for topical ophthalmic use only, not for injection.

Cyclomune® eye drops are associated with allergic reactions, even following a single dose. Discontinue using Cyclomune® immediately and contact your physician at the first sign of a rash or allergic reaction.

Avoid contaminating the applicator tip with eye, fingers or another source.

Patients should not wear contact lenses while using Cyclomune® eye drops.

Remove contact lenses before using Cyclomune® eye drops.

Contact lenses may be reinserted 15 minutes following administration of Cyclomune® eye drops

Wash your hands before using the eye drops.

Missing a dose

If you miss a dose you should instill it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not instill a double dose to make up for a missed one.


If an overdose occurs and you are not feeling well, stop taking the medication immediately. You should seek emergency medical attention or contact your healthcare provider immediately.


Store between 20 to 25 degrees C (68 to 77 degrees F), away from heat, moisture and light. Do not freeze. Discard immediately after expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Cyclomune® eye drops are:

  • allergic reactions
  • burning
  • blurred vision
  • clear or yellow fluid from the eye
  • difficulty with reading
  • eye pain
  • halos around lights
  • itching
  • redness
  • sticky or matted eyelashes
  • stinging
  • watery eye

Side effects occurrence does not only depend on the medication you are taking, but also on your overall health and other factors.


Cyclomune® eye drops are not for injection.

Do not use Cyclomune® eye drops if you are allergic to Cyclosporine or to other immunosuppressants.

Do not use Cyclomune® eye drops if you are allergic to any of the other ingredients comprised in Cyclomune® eye drops.

Do not use Cyclomune® eye drops if you have ever had severe allergic reactions associated with using antibiotics.

Inform your doctor if you had an eye infection from herpes virus in the past before using Cyclomune® eye drops.

Do not use Cyclomune® eye drops if you are taking any medicines to treat glaucoma.

Do not use Cyclomune® eye drops if you are using eye drops containing steroids as these might increase the risk of side effects.

Do not use Cyclomune® eye drops if you are pregnant, plan to have a baby or are breastfeeding.

Discontinue using Cyclomune® eye drops immediately and contact your physician at the first sign of a rash or allergic reaction.

Q: What is Cyclomune® eye drops used for?

A: Cyclomune® eye drops are used to treat chronic dry eye disease due to inflammation. Cyclomune® is designed in a form of eye drops which help increase eyes’ natural ability to produce tears. The medication is used in patients over 16 years of age.

Q: Can Cyclomune® eye drops be used in children?

A: Cyclomune® eye drops can be used only in patients over 16 years of age.

Q: Are Cyclomune® eye drops safe in pregnancy?

A: It is advisable not to use Cyclomune® eye drops during pregnancy until considered absolutely necessary by your physician.

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